NuPetit Necrosis, calcification
NuPetit Necrosis,
calcification, and vascular extension may be present in the central area.
Immunohistochemical stains provide definitive diagnosis with the smooth muscle
stains actin and vimentin being positive and S100 (positive in neurofibroma)
and GLUT-1 (positive in infantile hemangioma) being negative. The natural
history of IM is of gradual regression, possibly due to apoptosis, over the
first few years of life, although some lesions exhibit an initial phase of
rapid growth [17]. Of note, bony involvement can result in pathological
fractures [11]. Visceral IM portends a poor prognosis with a 33 to 75%
mortality rate, primarily due to mass effect on the organs [7, 12]. Tumors have
been reported to involve the pulmonary, cardiac, gastrointestinal, and central
nervous systems,
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